It’s called Bicycle Face, and it was actually considered it a serious health issue in the nineteenth century. The definition varies from source to source, but the general consensus was that women who biked too much would develop a chronic look of exhaustion and strain. This could include tight lips, a flushed face, harsh wrinkles, and bulging eyes with dark circles underneath.
So why bicycles specifically? In the late nineteenth century, biking while female was considered to be quite a feminist thing to do, it being a man’s game. The more women took to the wheel, the more publications like London’s National Review warned women of the “hidden dangers of cycling." Bicycle Face notwithstanding, female cyclists also had to follow a long list of arbitrary rules and were warned that it could cause heart palpitations, depression, and other serious (and totally false) health problems.
Making up things for women to feel insecure about is obviously nothing new. As women living in a consumer culture, it’s important to figure out when companies are trying to sell you something you don’t need (Vajazzle kits, anyone?). Thankfully, the Bike Face phenomenon was dispelled and ultimately forgotten about by the end of the 1890s, so as far as anti-Bike Face creams go, you probably won’t find too many of those at the drug store.